Probiotics during Covid

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Trends in Probiotics
Title: A Comprehensive Review of Probiotics and Their Uses for Control of Viral Infections in the Wake of Pandemic Covid-19

Journal: Tropical journal of Pharmaceutical and Life Sciences With this study we attempt to see how probiotics can be employed to combat viral diseases. There is a very unique mechanism through which viruses are eliminated by probiotics – a simulation of type 1 interferon production occurs via the activation of dendritic cells in the body, upon consuming probiotics. Though we have yet to see a proven cure for COVID-19, several clinical trials are underway. Studies show the sensitivity coronavirus has when exposed to IFN. Given how probiotics have the ability to initiate interferon production, their antiviral and immunomodulatory capabilities are used for the prophylaxis of COVID-19. With the world economy in shambles due to the coronavirus, probiotics are being increasingly noticed as one of the most efficient solutions against COVID-19.
Title: Antiviral Probiotics: A New Concept in Medical Sciences
 
Journal: New Insights on Antiviral Probiotics.
 
In the recent decades we have

seen the impact probiotics have had on animal and human health. From mild infections to severe health threats, probiotics protect the host from a variety of diseases. Researchers back in the 1990s believed that the effect of probiotics was limited to just the gut microbiota and that they could only restore the gut flora, preventing pathogenic bacteria from triggering astroenteritis. However, contrary to this, recent studies have shown that immunomodulatory activity is the most important mechanism probiotics are responsible for. With this information as a base, researchers started to evaluate the effect of some immunobiotics on both pathogenic bacteria and viruses, including enteric and respiratory viruses. Many believe that probiotics are great antiviral agents and have a wide variety of applications in the field!
Title: Handbook of COVID-19 Prevention and Treatment 
Publisher: Zhejiang University School of Medicine
This is an in-depth handbook for the prevention of COVID-19 and its treatment. Covering over 20 areas pertaining to handling the coronavirus and those affected by it, this handbook aims to provide some much-needed information to the public. This handbook highlights the courage and sacrifice demonstrated by healthcare professionals everywhere. To many, this handbook may provide a small piece of information previously unknown, which could be used to save someone’s life! The Jack Ma foundation initiated this program and AliHealth provided the necessary technical support. There might be certain errors since new discoveries are being made daily, regarding COVID-19.

Title: Using Probiotics to Flatten the Curve of Coronavirus Disease COVID-2019 Pandemic 
 
Journal: Frontiers in Public Health
 
Even though countries are following social distancing, better hygiene practices and screening techniques, COVID-19 still continues to progress rapidly. While drug therapies and vaccines are in the making, they might not be available for a long time! Therefore, additional preventive measures are the need of the hour. COVID-19 has symptoms that vary from mild to extremely life-threatening. While the initial signs are identified through flu-like symptoms, there are some very dangerous ones like acute respiratory distress syndrome (ARDS) and multiple organ failure. Though SARS-CoV-2 primarily spreads through respiratory droplets, it is seen that even the gut contributes towards the pathogenesis of COVID-19. Several studies show that specific probiotics, which are essentially beneficial microorganisms, help prevent bacterial and viral infections, including gastroenteritis, sepsis and respiratory tract infections (RTIs).
 
Title: Probiotics in viral infections, with a focus on COVID-19: A Systematic Review 
 
Publisher: Research gate
 

COVID-19, the newly discovered deadly virus disease can be affected by probiotics. Hence, this study was carried out to review the possible effects and associations of probiotics on viral infections, especially SARS-CoV-2. Studies were collected from multiple sources to identify content documenting the effect of probiotics on interleukins, virus titres and antibody production, with special emphasis on SARS-CoV-2. From a total of 93 records, 21 studies were classified into three main domains based on the impact of probiotics.

1. The level of interleukins (n=7)

2. Virus titres reduction (n=2)

3. Antibody production (n=12)

The production of proinflammatory interleukins and type 1 interferon (IFN) seemed to be the most prominent task carried out by probiotics. Randomized trials are necessary to find out which probiotic strains will be helpful in treating the COVID-19 virus.

 
Title: Can Probiotics and Diet Promote Beneficial Immune Modulation and Purine Control in Coronavirus Infection?
 
Ana H A Morais, Thais S Passos, Bruna L L Maciel, Juliana K da Silva-Maia Nutrients. 2020 Jun 10;12(6):1737.
 
Abstract: 
 

Infection caused by the SARS-CoV-2 coronavirus worldwide has led the World Health Organization to declare a COVID-19 pandemic. Because there is no cure or treatment for this virus, it is emergingly urgent to find effective and validated methods to prevent and treat COVID-19 infection. In this context, alternatives related to nutritional therapy might help to control the infection. This narrative review proposes the importance and role of probiotics and diet as adjunct alternatives among the therapies available for the treatment of this new coronavirus. This review discusses the relationship between intestinal purine metabolism and the use of Lactobacillus spp.